Expand this Topic clickable element to expand a topic
Skip to content
Optica Publishing Group
  • CLEO/Europe and EQEC 2011 Conference Digest
  • OSA Technical Digest (CD) (Optica Publishing Group, 2011),
  • paper CLEB2_2

Second-Harmonic Nanoparticles for Deep Tissue In Vivo Imaging

Not Accessible

Your library or personal account may give you access


Deep tissue in vivo imaging remains a great challenge and we propose to use second-harmonic radiation imaging probes (SHRIMPs) as long-term non bleaching biomarkers. We show that the contrast of SHRIMPs with autofluorescence and endogenous second-harmonic generation (SHG) signal is strong enough for imaging as deep as 100 um in the tail of a living rodent. Currently, optical microscopy often uses fluorescent markers such as green fluorescent proteins (GFPs) and quantum dots to specifically enhance the contrast of selected targets [1]. Such fluorescent agents, however, are limited by photobleaching, blinking, and phototoxicity.

© 2011 Optical Society of America

PDF Article
More Like This
Second-Harmonic Nanoparticles for Deep Tissue In Vivo Imaging

Rachel Grange, Thomas Lanvin, Chia-Lung Hsieh, Ye Pu, and Demetri Psaltis
CLEB2_2 European Quantum Electronics Conference (EQEC) 2011

In vivo Imaging Using Second-Harmonic Nanoparticles

Chia-Lung Hsieh, Thomas Lanvin, Rachel Grange, Ye Pu, and Demetri Psaltis
CThF3 CLEO: Science and Innovations (CLEO:S&I) 2011

Second Harmonic Nanoparticles in Biological Imaging

Ye Pu, Chia-Lung Hsieh, Rachel Grange, Xin Yang, Ioannis Papadopoulos, and Demetri Psaltis
C55 Conference on Lasers and Electro-Optics/Pacific Rim (CLEO/PR) 2011

Select as filters

Select Topics Cancel
© Copyright 2024 | Optica Publishing Group. All rights reserved, including rights for text and data mining and training of artificial technologies or similar technologies.