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Conferences > ACPC > 2015 > ASu1I > ASu1I.4

Optogenetic regulation of cellular functions through an intact skull using wavefront shaping

Jonghee Yoon, Minji Lee, KyeoReh Lee, Nury Kim, Jin Man Kim, Jongchan Park, Hyeonseung Yu, Chulhee Choi, Won Do Heo, and YongKeun Park

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Abstract

We present a method for activating photoactivatable proteins through a scattering skull using wavefront shaping. An illumination with a shaped wavefront formed optical focus through a scattering intact skull layer. We present in vitro demonstration of spatiotemporal regulation of cellular activities by activating photoactivatable proteins through intact skull layer.

© 2015 Optical Society of America

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