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Multiplexed COVID-19 Antibody Quantification from Human Sera Using Label-free Nanoplasmonic Biosensors

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Abstract

Serological assays can reveal immune status against COVID-19 informing individual and public healthcare decisions. We report a multiplexed and label-free nanoplasmonic biosensor that can discriminate healthy from convalescent samples with high sensitivity (95%) and specificity (100%) based on anti-SARS-CoV-2 antibody quantification. Our results show high concordance (R~ 0.87) with commercial assays in detecting anti-SARS-CoV-2 antibodies.

© 2022 The Author(s)

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