Abstract
Measurements of the time-dependent intensity of transmitted light through a highly scattering tissue phantom have been compared with an analytical model which describes the sensitivity of that intensity to localized changes in optical properties. A least-squares fitting procedure is employed to investigate the accuracy with which the model can predict the true displacement between a single embedded inhomogeneity and the line-of-sight across the phantom. The embedded object has twice the scatter and absorption coefficient of the surrounding medium. A further fitting procedure was used to derive the amplitudes of the measurement perturbations as the line-of-sight is translated towards the inhomogeneity. Results show that the diffusion perturbation amplitude provides inherently greater spatial resolution than the absorption perturbation amplitude.
© 1996 Optical Society of America
PDF ArticleMore Like This
Jeremy C. Hebden, Florian E. W. Schmidt, Martin E. Fry, Elizabeth M. C. Hillman, Martin Schweiger, David T. Delpy, and Simon R. Arridge
AMC4 Biomedical Topical Meeting (BIOMED) 1999
M. G. Nichols, E. L. Hull, and T. H. Foster
AP2 Biomedical Optical Spectroscopy and Diagnostics (BIOMED) 1996
Johannes Swartling, Antonio Pifferi, Eleonora Giambattistelli, Ekaterine Chikoidze, Alessandro Torricelli, Paola Taroni, Magnus Andersson, Anders Nilsson, and Stefan Andersson-Engels
5138_80 European Conference on Biomedical Optics (ECBO) 2003