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Distortion matrix concept for deep imaging in optical microscopy

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Abstract

In optical imaging, light propagation is affected by the medium inhomogeneities. Adaptive optics has been employed to compensate for sample-induced aberrations but the field-of-view is often limited to a single isoplanatic patch. Here, we propose a non-invasive approach based on the distortion matrix concept. This matrix basically connects any focusing point with the distorted part of its wave-front in reflection. Its time- reversal and entropy analysis allows to correct for high-order aberrations over multiple isoplanatic areas. We demonstrate a Strehl ratio enhancement up to 2500 and a diffraction- limited resolution until a depth of ten scattering mean free paths through an opaque cornea.

© 2020 The Author(s)

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