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Endogenous Fluorescence Monitoring In Vivo as an Assay for Cellular Damage in Photodynamic Therapy

Brian W. Pogue, Jonathan D. Pitts, Mary-Ann Mycek, Roger D. Sloboda, Carmen M. Wilmot, John F. Brandsema, and Julia A. O'Hara

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Abstract

The endogenous fluorescence signal attributed to NADH is decreased in response to photodynamic damage to cells and tissues [1]. This is being developed as a dosimetry tool to provide a direct measure of in vivo dose deposition.

© 2002 Optical Society of America

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