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A new fluorometric and optical approach for tracking of intracellular calcium, blood volume and oxygenation changes in the rat brain in vivo

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Abstract

The measurement of local changes in brain hemodynamics and oxygenation induced by cognitive tasks is widely used to advance our understanding of the neural bases of perception, attention, memory, addiction processes and language. For example, functional magnetic resonance imaging (fMRI) and positron emission tomography (PET) record local fluctuations in brain hemodynamics while electroencephalography (EEG) and magnetoencephalograpy (MEG) measure current flows induced by synaptic activity. EEG and MEG have high temporal resolution while fMRI has high spatial resolution; Efforts to enhance our understanding of neurocognitive processes now focus on integrating these methodologies during activations studies. The physiological coupling between local electrical activity and hemodynamic signals is still not understood and multi-modality integrative approaches (MEG and fMRI) can provide a new quantitative characterization of the relationship between the electrophysiological and hemodynamic phenomena to our further understanding.

© 2004 Optical Society of America

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