Abstract

Endomicroscope for in vivo imaging at the cellular level has been developed. Endomicroscope (Endoscopic micro confocal scanning microscope) is a laser scanning microscope extremely miniaturized with micromachining technology, and is built in at the distal end of the probe. Endomicroscope has a lateral resolution of 1μm allowing visualization of structures at the cellular level. In vivo imaging of the cell nuclei and membrane without staining has been achieved with human oral mucosa using 3.4mm diameter flexible probe which can be inserted into Endoscopic instrumentation channel.

© 2004 Optical Society of America