Oblique-Incidence Reflectivity Difference Microscopes for Label-Free High-Throughput Detection of Biochemical Reactions in Microarray Format

X. D. Zhu; J. P. Landry; Y. S. Sun; J. P. Gregg; K. S. Lam; X. W. Guo

doi:10.1364/BIO.2006.TuC8

Biomedical Optics
Technical Digest (CD) (Optica Publishing Group, 2006),
paper TuC8
•https://doi.org/10.1364/BIO.2006.TuC8

Oblique-Incidence Reflectivity Difference Microscopes for Label-Free High-Throughput Detection of Biochemical Reactions in Microarray Format

X. D. Zhu, J. P. Landry, Y. S. Sun, J. P. Gregg, K. S. Lam, and X. W. Guo

Biomedical Topical Meeting 2006

Fort Lauderdale, Florida United States
19–22 March 2006
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Molecular Imaging and Drug Discovery (TuC)

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X. D. Zhu, J. P. Landry, Y. S. Sun, J. P. Gregg, K. S. Lam, and X. W. Guo, "Oblique-Incidence Reflectivity Difference Microscopes for Label-Free High-Throughput Detection of Biochemical Reactions in Microarray Format," in Biomedical Optics, Technical Digest (CD) (Optica Publishing Group, 2006), paper TuC8.

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Abstract

We describe recently developed oblique-incidence optical reflectivity difference microscopes for label-free/high-throughput detection of biomolecular reactions on DNA/protein microarrays. We present examples of application of this technique to DNA-DNA hybridization, antibody-antigen capture, and protein-small-molecule binding reactions.

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