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Fluorescence Molecular Tomography Of Small Animals Using The Radiative Transfer Equation For Curved Geometries

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Abstract

We have developed a fluorescence image reconstruction algorithm for three-dimensional whole-body small animal imaging. Our method uses non-contact fluorescent light measurement data on the tissue surface of the animal and reconstructs the three-dimensional unknown fluorophore concentration inside the tissue. The image reconstruction technique employs a light propagation model based on the equation of radiative transfer, which is solved on a structured Cartesian grid by a finite-difference method. A blocking-off approach takes the curved tissue surface geometry of the animal into account. Our proposed method has the advantage that fast numerical solvers for the equation of radiative transfer can be used.

© 2006 Optical Society of America

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