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Performance of the Red-shifted fluorescent proteins in multispectral optoacoustic tomography (MSOT)

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Abstract

The use of new red shifted fluorescence proteins (FPs that emit beyond 600 nm) with whole-body Multispectral Optoacoustic Tomography (MSOT) opens exciting new opportunities to study transcription, protein function and cell trafficking non-invasively and in-vivo. We report on the optoacoustic performance of red-shifted FPs in deep-tissue mouse multispectral optoacoustic tomography, that in particular cases can be more than 3 orders of magnitude better.

© 2010 Optical Society of America

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