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Non-invasive Optical Detection of Cell Differentiation Status Using Endogenous Sources of Optical Contrast

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Two-photon fluorescence and second harmonic generation images of mesenchymal stem cells undergoing osteoblastic differentiation demonstrate the cell redox ratio of FAD/(NADH+FAD) can serve as non-invasive biomarker of cell differentiation status.

© 2012 Optical Society of America

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