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Conferences > BIOMED > 2012 > BSu3A > BSu3A.35

Fiber-optic Second Harmonic Generation Endomicroscopy: A Potential tool for Diagnosis of Preterm Birth

Yuying Zhang, Meredith L. Akins, Kartikeya Murari, Ming-Jun Li, Katherine Luby-Phelps, Mala Mahendroo, and Xingde Li

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Abstract

We present a fiber-optic scanning second harmonic generation (SHG) endomicroscopy system that can detect the morphological changes in cervical collagen fiber during gestation with sub-micrometer resolution. Our preliminary results suggest a promising role of the SHG endomicroscopy technology for assessing abnormal remodeling of cervical collagen fiber associated with preterm birth.

© 2012 Optical Society of America

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