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Methods For Simultaneous Optical And Electrical Measurement Of Neurovascular Coupling in Awake Rats

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Abstract

Neurovascular coupling, the coordination of changes in metabolic demand from neuronal tissue with vascular regulation of localized blood perfusion, has previously been investigated by diffuse optical imaging and trans-cranial EEG in anesthetized rats. To overcome the profound impact of anesthetics on brain hemodyamics and electrical activity, we have developed an implantable electro-optical probe for longitudinal measurements in fully awake rats.

© 2012 Optical Society of America

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