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Interferometric Synthetic Aperture Microscopy with Computational Adaptive Optics for High-Resolution Tomography of Scattering Tissue

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Abstract

Interferometric synthetic aperture microscopy (ISAM) is a computed imaging technique to overcome the depth-of-field limitations in optical coherence tomography/microscopy (OCT/OCM). However, the presence of optical aberrations (which typically increase with NA) can degrade the resolution of ISAM reconstructions. We demonstrate a computational adaptive optics (CAO) method to correct aberrations of a virtual (or computed) pupil. Three-dimensional datasets in rabbit muscle tissue show that ISAM with CAO astigmatism correction results in a higher resolution reconstruction than uncorrected ISAM or standard OCT/OCM. We also present our work on high-speed 2D and pseudo-3D ISAM reconstruction using a graphic processing unit (GPU). These results demonstrate ISAM with computational aberration correction in highly scattering tissue. They also demonstrate that with precise high-speed scanning, volumetric ISAM can be performed without phase noise correction, and suggest that with GPU-based processing, real-time volumetric ISAM is feasible.

© 2012 Optical Society of America

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More Like This
Broadband optical interferometric tomography with computational adaptive optics using ‘guide stars’

Steven G. Adie, Nathan Shemonski, Benedikt W. Graf, Adeel Ahmad, P. Scott Carney, and Stephen A. Boppart
FM3D.3 Frontiers in Optics (FiO) 2012

High-speed Interferometric Synthetic Aperture Microscopy on a Graphics Processing Unit

Adeel Ahmad, Nathan Shemonski, Steven G. Adie, Heeseok Kim, Wen-Mei W. Hwu, P. Scott Carney, and Stephen A. Boppart
FM4D.2 Frontiers in Optics (FiO) 2012

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