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Conferences > BIOMED > 2014 > BM3A > BM3A.79

Oxygen Imaging by Cerenkov-Excited Phosphorescence in Glioma Tumors during Radiation Therapy

Robert W. Holt, Rongxiao Zhang, Tatiana V. Esipova, Sergei A. Vinogradov, David J. Gladstone, and Brian W. Pogue

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Abstract

Cherenkov photons generated during radiation therapy excite a phosphorescent agent, Platinum(II)G4, whose triplet lifetime is sensitive to pO2. Phosphorescence emission is measured at the boundary of rodent glioma subjects and beam-guided recovery is outlined for local pO2 estimation.

© 2014 Optical Society of America

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