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Conferences > BIOMED > 2014 > BT3A > BT3A.39

The Role of Nuclear Nano-Environment on DNA Dehybridization

Luay Matthew Almassalha, Lusik Cherkezyan, Greg Putzel, Vadim Backman, and Igal Szleifer

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Abstract

Using coarse-grain molecular dynamics simulations and UV spectroscopy, we study the role of the macromolecular crowding on the structure of double stranded DNA. Our results show that crowding has a non-monotonic influence on DNA dehybridization.

© 2014 Optical Society of America

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