Quantitative Large-Area Agglutination Assay Sensing of Protein Molecules in Solution

Colin J. Potter; Colin J. Potter; Zhen Xiong; Euan McLeod

doi:10.1364/BODA.2021.DM1A.7

Biophotonics Congress 2021
OSA Technical Digest (Optica Publishing Group, 2021),
paper DM1A.7
•https://doi.org/10.1364/BODA.2021.DM1A.7

Quantitative Large-Area Agglutination Assay Sensing of Protein Molecules in Solution

Colin J. Potter, Zhen Xiong, and Euan McLeod

Bio-Optics: Design and Application 2021

Washington, DC United States
12–16 April 2021
ISBN: 978-1-943580-85-9

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Quantitative Phase Imaging and Mechanics (DM1A)

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C. J. Potter, Z. Xiong, and E. McLeod, "Quantitative Large-Area Agglutination Assay Sensing of Protein Molecules in Solution," in Biophotonics Congress 2021, C. Boudoux, K. Maitland, C. Hendon, M. Wojtkowski, K. Quinn, M. Schanne-Klein, N. Durr, D. Elson, F. Cichos, L. Oddershede, V. Emiliani, O. Maragò, S. Nic Chormaic, N. Pégard, S. Gibbs, S. Vinogradov, M. Niedre, K. Samkoe, A. Devor, D. Peterka, P. Blinder, and E. Buckley, eds., OSA Technical Digest (Optica Publishing Group, 2021), paper DM1A.7.

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Abstract

A portable quantitative large-area binding sensor based on lensfree holographic microscopy, microfluidics, a custom LED array, and computational image processing and feature quantification algorithm has been implemented to sense proteins in solution through microbead agglutination.

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