Chromatin Reprogramming via Contact Guidance-Induced Nuclear Deformation Promotes Stem Cell Differentiation

Vasundhara Agrawal; Xinlong Wang; Yue Li; Ranya K.A. Virk; Priyam A. Patel; Surbhi Jain; Nancy Rivera-Bolanos; Jane Frederick; Eric Roth; Reiner Bleher; Chongwen Duan; Bin Jiang; Panagiotis Ntziachristos; Vadim Backman; Guillermo A. Ameer

doi:10.1364/BODA.2021.DTu1A.1

Biophotonics Congress 2021
OSA Technical Digest (Optica Publishing Group, 2021),
paper DTu1A.1
•https://doi.org/10.1364/BODA.2021.DTu1A.1

Chromatin Reprogramming via Contact Guidance-Induced Nuclear Deformation Promotes Stem Cell Differentiation

Vasundhara Agrawal, Xinlong Wang, Yue Li, Ranya K.A. Virk, Priyam A. Patel, Surbhi Jain, Nancy Rivera-Bolanos, Jane Frederick, Eric Roth, Reiner Bleher, Chongwen Duan, Bin Jiang, Panagiotis Ntziachristos, Vadim Backman, and Guillermo A. Ameer

Bio-Optics: Design and Application 2021

Washington, DC United States
12–16 April 2021
ISBN: 978-1-943580-85-9

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V. Agrawal, X. Wang, Y. Li, R. K. A. Virk, P. A. Patel, S. Jain, N. Rivera-Bolanos, J. Frederick, E. Roth, R. Bleher, C. Duan, B. Jiang, P. Ntziachristos, V. Backman, and G. A. Ameer, "Chromatin Reprogramming via Contact Guidance-Induced Nuclear Deformation Promotes Stem Cell Differentiation," in Biophotonics Congress 2021, C. Boudoux, K. Maitland, C. Hendon, M. Wojtkowski, K. Quinn, M. Schanne-Klein, N. Durr, D. Elson, F. Cichos, L. Oddershede, V. Emiliani, O. Maragò, S. Nic Chormaic, N. Pégard, S. Gibbs, S. Vinogradov, M. Niedre, K. Samkoe, A. Devor, D. Peterka, P. Blinder, and E. Buckley, eds., OSA Technical Digest (Optica Publishing Group, 2021), paper DTu1A.1.

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Abstract

Using chromatin packing macromolecular crowding (CPMC) model predictions and nanoscale imaging and sequencing studies, we demonstrate that micropillar structures enhance osteogenic differentiation by decreasing chromatin packing scaling in hMSCs and consequently increasing lineage-specific responsiveness.

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