Add to BibSonomyAbstract
Time-resolved reflectance spectroscopy was used to investigate the effects of photodynamic irradiation on the in vivo absorption properties of disulphonated Aluminum Phthalocyanine (AlS2Pc) in tumor-bearing mice. Mice bearing tumors injected either intramuscularly or intradermally were administered with 5 mg/kg body weight of AlS2Pc. Uptake times of 3 h and 12 h were examined. Absorption spectra were measured from 610 to 700 nm before, during and after the irradiation. The administration of a therapeutic light dose causes a blue-shift and a reduction in the drug absorption, which are more marked 3 h than 12 h after drug injection.
© 2000 Optical Society of America
PDF ArticleMore Like This
Rinaldo Cubeddu, Cosimo D’Andrea, Antonio Pifferi, Paola Taroni, Alessandro Torricelli, Gianluca Valentini, and Gianfranco Canti
MD2 Biomedical Optical Spectroscopy and Diagnostics (BIOMED) 2000
D. Parmeswaran, P. Aruna, P.K. Gupta, and S. Ganesan
4433_128 European Conference on Biomedical Optics (ECBO) 2001
R. Cubeddu, M. Musolino, A. Pifferi, P. Taroni, G. Valentini, and G. Canti
CThC6 The European Conference on Lasers and Electro-Optics (CLEO/Europe) 1994