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Time-resolved spectroscopy system for tissue oxygenation measurement

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Abstract

Time-resolved spectroscopy (TRS), which measures the intensity of light in time domain, enables us to estimate the photon pathlength distribution within the tissues by converting time into distance. Thus, quantitative measurement of tissue oxygenation is achieved by analyzing the data with microscopic Beer-Lambert law (1) or photon diffusion theory (2). Moreover, it can provide complete data sets regarding the temporal response of the subject, so that time-gated imaging may be possible in optical computed tomography, improving the spatial resolution of the reconstructed images.

© 2000 Optical Society of America

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