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Conferences > BRAIN > 2015 > BrM3B > BrM3B.2

A multi modal clearing method for brain imaging

Irene Costantini, Anna Letizia Allegra Mascaro, Antonino Paolo Di Giovanna, Ludovico Silvestri, Marie Caroline Müllenbroich, Leonardo Sacconi, and Francesco S. Pavone

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Abstract

In this work we investigate the effectiveness of a water-soluble agent, the 2,2′-thiodiethanol (TDE) to clear mouse and human brain. TDE is suitable with two-photon fluorescence microscopy and in combination with CLARITY with light sheet microscopy.

© 2015 Optical Society of America

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