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Our team is developing a next-generation high-throughput random-access imaging system for real-time monitoring of sensory-driven synaptic activity. This monitoring takes place across all inputs to single living neurons in the context of the intact cerebral cortex, in order to better understand how these synaptic signals are integrated and processed. Our first target is to monitor calcium signals from approximately 10,000 locations corresponding to all excitatory synapses of a single neuron with 100 ms temporal resolution. While calcium imaging with GCaMP is well-established, the RCaMP excitation wavelength at about 1050 nm is more compatible with high power Yb-fiber based femtosecond laser sources.
© 2016 Optical Society of America
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