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Conferences > CLEO > 1995 > CThI > CThI8
  • Conference on Lasers and Electro-Optics
  • OSA Technical Digest (Optica Publishing Group, 1995),
  • paper CThI8

Selective laser spectroscopy of hematoporphyrin diacetate in membranes of lecithin liposomes

M. A. Drobizhev and M. N. Sapozhnikov

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Abstract

Porphyrins are used as photosensitizers for the diagnosis and the photodynamic therapy of cancer.1 Photodynamic therapy is based on a selective retention of porphyrins by the tumor tissue and on light-induced damage of cell membranes mediated by the porphyrin photosensitizer. The photodynamic efficiency of porphyrins has been shown to depend on their solubility in the lipid membrane.2 However, the precise location of porphyrin molecules in the membrane is still unknown.

© 1995 Optical Society of America

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