Abstract
Several forms of optical spectroscopy have been investigated as potential diagnostic tools for early noninvasive diagnosis of cancer and other diseases. Many tissue pathologies involve changes in celluler biochemistry and architecture, which are observed in backscattered light.1 Most tissue spectroscopy systems implemented to date do not incorporate means for optical path length selection. They are, thus, insensitive to Spectroscopic variations with depth,and compromised in lateral resolution due to light scattering. Optical coherence tomography (OCT) is a novel imaging technique that utilizes coherence range gating to perform noninvasive micron-scale resolution subsurface imaging of biological tissue microstructure.2 Implementations of OCT, which take advantage of the spectral bandwidth of low coherence sources for tissue spectroscopy, have not yet been reported.
© 1996 Optical Society of America
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