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  • Conference on Lasers and Electro-Optics
  • OSA Technical Digest (Optica Publishing Group, 2002),
  • paper CThW3

Probing Endogenous Fluorophores in Cellular Cancer Models Using Temporally and Spectrally Resolved Laser Induced Fluorescence

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Abstract

Previous experiments on model human bronchial epithelial (HBE) cells demonstrated reduced autofluorescence upon carcinogen transformation.1 Here we show that autofluorescence intensity differences between cell lines are mainly due to differing concentrations of protein-bound mitochondrial NADH (the reduced form of nicotinamide-adenine-dinucleotide), a cellular metabolic co-factor.

© 2002 Optical Society of America

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