Real-time single-molecule co-immunoprecipitation analyses reveal cancer-specific Ras signaling dynamics

Hong-Won Lee; Hong-Won Lee; Taeyoon Kyung; Taeyoon Kyung; Janghyun Yoo; Janghyun Yoo; Tackhoon Kim; Chaeuk Chung; Ji Young Ryu; Ji Young Ryu; Hanki Lee; Kihyun Park; Sangkyu Lee; Sangkyu Lee; Walton D. Jones; Dae-Sik Lim; Changbong Hyeon; Won Do Heo; Won Do Heo; Tae-Young Yoon; Tae-Young Yoon

2015 Conference on Lasers and Electro-Optics Pacific Rim
(Optica Publishing Group, 2015),
paper 28H1_5

Real-time single-molecule co-immunoprecipitation analyses reveal cancer-specific Ras signaling dynamics

Hong-Won Lee, Taeyoon Kyung, Janghyun Yoo, Tackhoon Kim, Chaeuk Chung, Ji Young Ryu, Hanki Lee, Kihyun Park, Sangkyu Lee, Walton D. Jones, Dae-Sik Lim, Changbong Hyeon, Won Do Heo, and Tae-Young Yoon

Conference on Lasers and Electro-Optics/Pacific Rim 2015

Busan Republic of Korea
24–28 August 2015
ISBN: 978-1-4673-7110-0

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Plasmonics in Biophotonics (28H1)

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H. Lee, T. Kyung, J. Yoo, T. Kim, C. Chung, J. Y. Ryu, H. Lee, K. Park, S. Lee, W. D. Jones, D. Lim, C. Hyeon, W. D. Heo, and T. Yoon, "Real-time single-molecule co-immunoprecipitation analyses reveal cancer-specific Ras signaling dynamics," in 2015 Conference on Lasers and Electro-Optics Pacific Rim, (Optica Publishing Group, 2015), paper 28H1_5.

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Abstract

The conventional co-immunoprecipitation provides static and qualitative information about protein-protein interactions. Lee et al. report real-time imaging of co-immunoprecipitation process with single-molecule resolution, allowing for characterization of the native Ras proteins derived from individual cancers.

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