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Conferences > CLEOPR > 2017 > EB > s1032
  • 2017 Conference on Lasers and Electro-Optics Pacific Rim
  • (Optica Publishing Group, 2017),
  • paper s1032

Polymeric Microneedles’ Swelling Property Characterizations using Micro-Optical Coherence Tomography

Xiaojun Yu, Razina Z. Seeni, Linbo Liu, and Chenjie Xu

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Abstract

We report on noninvasive characterization of MNs’ real-time swelling property in mice-skin using a lab-built microoptical coherence tomography (μOCT). Specifically, we propose to encapsulate the iron-oxide (Fe3O4) nanoparticles into polymeric MNs as contrast agent to enhance OCT image contrast, and then evaluate its influences on contrast enhancement quanti- tatively. The MNs’ real-time temporal swelling behaviors in miceskin are recorded and analyzed. This is the first quantitative study on MNs’ temporal swelling property in biological tissue using μOCT.

© 2017 Optical Society of America

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