Abstract

This paper demonstrates the use of Guided Mode Resonance (GMR) optical sensor platform for detection of Glycated Hemoglobin (HbA1c) in human blood. HbA1c is an importance biomarker for monitoring a long-term glucose level in diabetes patients. Here, the sensing approach utilizes boronate affinity by modification of the GMR surface with 3-Aminophenylboronic acid (PBA). The sensing signal is then measured via a resonance shift in a reflection spectrum as the change of the refractive index on the sensor surface. In preliminary experiment, standard HbA1c samples with concentration covering the detection range (5% and 10 %) are used. The results show a good trend of resonance shift corresponding to amount of HbA1c.

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