Abstract

Pharmaceutical fabrication processes often involve manipulating mixtures of particulates. Specifically granulation, which is the aggregation of small particles into larger ones, can induce undesirable changes to physical and chemical properties, and requires appropriate monitoring techniques. An optical monitoring is generally preferred due to its high detection speed, but with spectral domain methods, such as Raman spectroscopy, the recorded data depend simultaneously on various different sample properties, such as particle size, polymorphism, and chemical composition, making data interpretation problematic.¹

© 2007 IEEE