Abstract

The possibility to control surface properties of materials and to tailor behaviour of cells and biomolecules are the basic requirements in the development of a new generation biomaterials for applications in tissue engineering. Surface patterning on micro and nano- scale is critical to distinguish the effects of cell shape, focal adhesion, and ligand input for cell functions. Recently, much attention has been paid to laser-assisted micro and nanofabrication technologies to pattern surfaces with different topographies for providing valuable inside on cell-substrate junction [1]. Laser modification by pulses in the femtosecond time domain, provide a quality of modification of thin films of biopolymers that is unobtainable with longer pulses in the range of nanoseconds [2].

© 2017 IEEE