Abstract

As one of the most central kind of biomolecules under interest, lipids perform versatile roles in metabolism, structural maintenance, energy conservation as well as signal transmission [1]. Many techniques are developed and employed for lipids studies, including but not limited to lipophilic dyeing, mass spectroscopy, fluorescent and Raman microscopy et al [2]. However, these examinations of lipids hinge on biopsy invasion or external labeling, which demands complex sample preparation procedures and might incur toxicity or changes in metabolic conditions. Hence, a label-free and non-invasive imaging modality is desired for biomedical lipid studies, which eliminates biosafety concerns and allows easy implementation.

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