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Conferences > CLEO_QELS > 2021 > JTu2R > JTu2R.4

High contrast reporter cleavage detection for enhancing porous silicon sensor sensitivity

Rabeb Layouni, Michael Dubrovsky, Mengdi Bao, Haejun Chung, Ke Du, Svetlana V. Boriskina, Sharon M. Weiss, and Diedrik Vermeulen

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Abstract

We show the first experimental implementation of biosensing using high contrast reporter cleavage detection (HCRCD). HCRCD makes use of dramatic signal amplification caused by cleavage of high-contrast nanoparticle labeled reporters instead of the capture of low-index bio- molecules.

© 2021 The Author(s)

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