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Photonic Crystal Enhanced Emission and Blinking Suppression for Single Quantum Dot Digital Resolution Biosensing of Cancer-associated miRNA Biomarkers

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Abstract

We report 3,000-fold signal enhancement with blinking suppression capability and single QD sensitivity using low-NA lens. Applied toward miRNA detection assays, we achieve single-base mutation selectivity, and 10-attomolar detection limit.

© 2022 The Author(s)

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