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Detection of Single Nanoparticles Using Photonic Crystal Enhanced Microscopy

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Abstract

We demonstrate a label-free biosensor imaging approach that utilizes a photonic-crystal surface to detect attachment of individual nanoparticles down to ~65×30×30nm3. Matching nanoparticle plasmon resonant-frequency to the photonic-crystal resonance substantially increases sensitivity of the approach.

© 2014 Optical Society of America

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