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Intra-operative Brain Tumor Imaging

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Abstract

The accumulation of fluorescent protoporphyrin IX following oral delivery of 5-aminolevulinic acid proved highly specific for malignant glioma. Fluorescence imaging by surgical microscopes delineates tumor from normal brain during surgical resection. This approach enables a significant increase of cases with “safe gross total resection”, associated with longer progression free survival. Limitations and possible improvements are discussed.

© 2016 Optical Society of America

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More Like This
Intraoperative Demarcation of Tumor Borders by 5-ALA-induced Protoporphyrin IX Fluorescence for the Resection of Malignant Glioma

H. Stepp, R. Baumgartner, K. Bise, S. Stocker, S. Wagner, W. Stummer, and H.J. Reulen
TSuB3 Therapeutic Laser Applications (TLA) 1998

Protoporphyrin IX Fluorescence Imaging of Glioma Tumor Growth in the Murine Brain

Summer L. Gibbs, Julia A. OHara, P. Jack Hoopes, and Brian W. Pogue
SD2 Biomedical Topical Meeting (BIO) 2006

Photo-acoustic imaging of blue nanoparticle targeted brain tumor for intra-operative glioma delineation

Aniruddha Ray, Xueding Wang, Yong-Eun Koo Lee, HoeJin Hah, Gwangseong Kim, Thomas Chen, Daniel Orrienger, Oren Sagher, and Raoul Kopelman
808906 European Conference on Biomedical Optics (ECBO) 2011

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