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Fluorescence imaging in the upper gastrointestinal tract for detection of dysplastic changes

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Abstract

During endoscopy of the esophagus fluorescence images were recorded at a delay of 20 ns after pulsed laser excitation simultaneously with conventional reflected white light images. To label malignant cells (dysplasia, tumor) 5-aminolaevulinic acid was applied prior to fluorescence guided biopsy. In this way premalignant and malignant lesions were detected not seen previously during routine endoscopy.

© 2001 OSA/SPIE

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