Testing of efficacy of photodynamic therapy with a new photosensitizer - a of chlorin e6 derivative (BLC 1010)

E. Ph. Stranadko; M.V. Riabov; N. N.VoIkova; S. Spaniol; W. Rauschning; N.E. Nifantiev

doi:10.1364/ECBO.2001.4433_155

Laser-Tissue Interactions, Therapeutic Applications, and Photodynamic Therapy
Technical Digest Series (Optica Publishing Group, 2001),
paper 4433_155
•https://doi.org/10.1364/ECBO.2001.4433_155

Testing of efficacy of photodynamic therapy with a new photosensitizer - a of chlorin e6 derivative (BLC 1010)

E. Ph. Stranadko, M.V. Riabov, N. N.VoIkova, S. Spaniol, W. Rauschning, and N.E. Nifantiev

European Conference on Biomedical Optics 2001

Munich Germany
18–21 June 2001
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Photodynamic Therapy III (4433)

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E. P. Stranadko, M. V. Riabov, N. N.VoIkova, S. Spaniol, W. Rauschning, and N. E. Nifantiev, "Testing of efficacy of photodynamic therapy with a new photosensitizer - a of chlorin e6 derivative (BLC 1010)," in Laser-Tissue Interactions, Therapeutic Applications, and Photodynamic Therapy, Technical Digest Series (Optica Publishing Group, 2001), paper 4433_155.

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Abstract

Efficacy of PDT with new chlorin e6 photosensitizer (BLC 1010) has been tested in 72 cancer patients. 44 patients (61 %) achieved a complete response and 39 % of the patients a partial response (28 patients, including 15 patients treated for palliation).

Rapid elimination of BLC 1010 from the organism solves the problem of skin phototoxicity encountered in PDT up to now. This property together with its high tumor to normal ratio makes it a promising photosensitizer for PDT. Further advantage is that portable diode lasers with proper wavelength are available.

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