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Conferences > ECBO > 2001 > 4433 > 4433_81

Interferometric Detection of Laser Induced Microbubbles in the Retinal Pigment Epithelium

Jörg Neumann and Ralf Brinkmann

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Abstract

We developed an interferometric technique in order to detect microbubble formation within porcine retinal pigment epithelial (RPE) cells ex vivo after short pulsed laser exposure (527 nm, 350ns). The irradiated surface of the RPE tissue samples was monitored by a Michelson interferometer. The obtained interferometric transients revealed bubble dynamics and were compared to optoacoustic transients recorded simultaneously. This interferometric technique might be useful for in vivo dosimetry during selective RPE-treatment.

© 2001 OSA/SPIE

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