Abstract

Molecular interaction especially biorecognitive binding can be visualized by metal cluster enhanced fluorescence. Fluorescent molecules that are bound within the electromagnetic field of a layer of metal clusters exhibit a strong boost in excitation as well as emission. We present a study, using novel surface enhanced chips in glass-slide-format, their set up, the micro arraying onto the surface, and the hybridization of oligonucleotides on these chips.

Compared to standard (glass slide) DNA chips, performance, fluorescent signals as well as signal to noise ratio were considerably higher.

© 2001 OSA/SPIE