Real Time Atomic Force Fluorescence-Microscopy on Living Cells

Jens Struckmeier; Erk Klopp; Matthias Born; Martin Hofmann; Damaris Rink; David B. Jones; Stefan Ecke; Hans-Jürgen Butt

doi:10.1364/ECBO.2001.4434_142

Hybrid and Novel Imaging and New Optical Instrumentation for Biomedical Applications
Technical Digest Series (Optica Publishing Group, 2001),
paper 4434_142
•https://doi.org/10.1364/ECBO.2001.4434_142

Real Time Atomic Force Fluorescence-Microscopy on Living Cells

Jens Struckmeier, Erk Klopp, Matthias Born, Martin Hofmann, Damaris Rink, David B. Jones, Stefan Ecke, and Hans-Jürgen Butt

European Conference on Biomedical Optics 2001

Munich Germany
18–21 June 2001
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Novel Techniques for Microscopy and Spectroscopy (4434)

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J. Struckmeier, E. Klopp, M. Born, M. Hofmann, D. Rink, D. B. Jones, S. Ecke, and H. Butt, "Real Time Atomic Force Fluorescence-Microscopy on Living Cells," in Hybrid and Novel Imaging and New Optical Instrumentation for Biomedical Applications, Technical Digest Series (Optica Publishing Group, 2001), paper 4434_142.

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Abstract

The reaction of bone cells after mechanical stimulation is a key issue in understanding the origins of osteoporosis. We investigate mechanical stimulation of osteoblasts and their reaction with a new combination of an atomic force apparatus with a fluorescence microscope. First measurements on the mechanically induced calcium response of osteoblasts are presented. The average threshold force for stimulation is 300nN and the dynamics of the calcium response is in the several tens of seconds range.

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