Fluorescence microscopy studies of a peripheral benzodiazepine receptor targeted molecular probe for brain tumor imaging

Laura Marcu; Laura Marcu; Laura Marcu; P. Thomas Vernier; H. Charles Manning; Sarah Salemi; Aimin Li; Cheryl M. Craft; Martin A. Gundersen; Darryl J. Bornhop

doi:10.1364/ECBO.2003.5141_64

Diagnostic Optical Spectroscopy in Biomedicine II
Proc. SPIE (Optica Publishing Group, 2003),
paper 5141_64
•https://doi.org/10.1364/ECBO.2003.5141_64

Fluorescence microscopy studies of a peripheral benzodiazepine receptor targeted molecular probe for brain tumor imaging

Laura Marcu, P. Thomas Vernier, H. Charles Manning, Sarah Salemi, Aimin Li, Cheryl M. Craft, Martin A. Gundersen, and Darryl J. Bornhop

European Conference on Biomedical Optics 2003

Munich Germany
ISBN: 0-8194-5011-1

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Tissue Florescence II (TFII)

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L. Marcu, P. T. Vernier, H. C. Manning, S. Salemi, A. Li, C. M. Craft, M. A. Gundersen, and D. J. Bornhop, "Fluorescence microscopy studies of a peripheral benzodiazepine receptor targeted molecular probe for brain tumor imaging," in Diagnostic Optical Spectroscopy in Biomedicine II, G. Wagnières, ed., Vol. 5141 of Proc. SPIE (Optica Publishing Group, 2003), paper 5141_64.

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Abstract

This study investigates the potential of a new multi-modal lanthanide chelate complex for specifically targeting brain tumor cells. We report here results from ongoing studies of up-take, sub-cellular localization and binding specificity of this new molecular imaging probe. Fluorescence microscopy investigations in living rat C6 glioma tumor cells demonstrate that the new imaging agent has affinity for glioma cells and binds to mitochondria.

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