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Conferences > ECBO > 2003 > PS > 5142_207

Saturation of a photochemical dose by photosensitizer bleaching during PDT

Boris Ya. Kogan

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Abstract

Photodynamic therapy (PDT) with total photobleaching of a photosensitizer (PS) was studied theoretically. The equations for spatial-temporal distribution of photochemical dose (PD) under various irradiations were obtained. Both surface irradiation and interstitial irradiation were considered. The possibilities of having constant therapeutic dose within a large extent of a tissue and even of obtaining the maximal dose at a particular depth were shown.

© 2003 SPIE

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