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Pathological Diagnosis of Bladder Cancer by Image Analysis of Hypericin Induced Fluorescence Cystoscopic Images

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Abstract

The potential of the photosensitizer hypericin-induced fluorescence in performing noninvasive optical biopsy to grade bladder cancer in vivo using fluorescence cystoscopic image analysis is investigated in this study. Preliminary results suggest a correlation between tissue fluorescence and cancer grade. A diagnostic algorithm developed based on colorimetric intensity ratios shows promising sensitivity and specificity in performing in vivo bladder cancer grading.

© 2005 Optical Society of America

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