Expand this Topic clickable element to expand a topic
Skip to content
Optica Publishing Group

White-light time-resolved reflectance spectroscopy for monitoring constituents concentrations in layered diffusive media

Not Accessible

Your library or personal account may give you access

Abstract

We performed reflectance measurements with a time-resolved white-light spectroscopy system to monitor concentrations changes in a two-layer liquid phantom with optical properties similar to human tissues. By varying the concentrations of three inks with different spectral features, we changed the absorption coefficient of the upper and lower layer to simulate either haemodynamics changes in the muscle covered by adipose layer, or functional brain activation with systemic response in the scalp. Data were analyzed by a time-resolved spectrally constrained fitting method based on a homogeneous model of photon diffusion. Although this approach is based on a homogeneous model and employs a single 2cm source-detector distance, the technique is able to monitor changes in the lower layer, while it is scarcely affected by variation in the upper layer. Preliminary in vivo measurements have been performed on one healthy volunteer to monitor oxy- and deoxy-haemoglobin changes in the muscle during arterial occlusion and in the brain during a motor task. Even if the overall sensitivity of the technique is reduced, in vivo results are in general agreement with the findings of dedicated system for tissue oximetry.

© 2007 SPIE

PDF Article
More Like This
Reconstruction of the absorption spectra of layered diffusive media by time-and space-resolved reflectance spectroscopy

Rinaldo Cubeddu, Cosimo D’Andrea, Antonio Pifferi, Paola Taroni, Alessandro Torricelli, and Gianluca Valentini
MG1 Biomedical Optical Spectroscopy and Diagnostics (BIOMED) 2000

Dynamic time-resolved diffuse spectroscopy based on white light generation in a photonic crystal fiber

C. D’Andrea, A. Bassi, J. Swartling, A. Pifferi, A. Torricelli, and R. Cubeddu
ThA1 European Conference on Biomedical Optics (ECBO) 2005

Monitoring muscle metabolic indexes by time-domain near infrared spectroscopy during knee flex-extension induced by functional electrical stimulation

Alessandro Torricelli, Davide Contini, Lorenzo Spinelli, Rinaldo Cubeddu, Franco Molteni, Simona Ferrante, Alessandra Pedrocchi, and Giancarlo Ferrigno
6629_57 European Conference on Biomedical Optics (ECBO) 2007

Select as filters


Select Topics Cancel
© Copyright 2024 | Optica Publishing Group. All Rights Reserved