Abstract
The concentration changes in oxygenated haemoglobin and deoxygenated haemoglobin in the brain cortex of guinea pigs associated with brain activation are measured from the multi-spectral images of the cortical tissue. The cortical tissue is observed through a thinned skull. The wavelength dependence of the optical path length is considered in the calculation of haemoglobin concentration. The results are compared with those obtained from the multi-spectral images of the exposed cortex to evaluate the influence of the thinned skull on the measurement of the concentration changes by multi-spectral imaging system. Although the skull thickness affected the sensitivity of the change in reflectance due to decrease in optical path in the cortical tissue, the influence of skull on the wavelength dependence of the optical path length can be ignored when the skull thickness is approximately less than 100 μm.
© 2007 SPIE
PDF ArticleMore Like This
K. Sakaguchi, S. Furukawa, E. Okada, T. Katsura, A. Maki, and H. Kawaguchi
TuI12 Biomedical Topical Meeting (BIOMED) 2006
K. Sakaguchi, T. Tachibana, K. Yokoyama, S. Furukawa, E. Okada, T. Katsura, A. Maki, and H. Kawaguchi
WH4 European Conference on Biomedical Optics (ECBO) 2005
Naotaka Sakashita, Koichiro Sakaguchi, Satoshi Matsuo, Haruka Nakayama, Takushige Katsura, Kyoko Yamazaki, Naoki Tanaka, Hideo Kawaguchi, Atsusi Maki, and Eiji Okada
7369_0Z European Conference on Biomedical Optics (ECBO) 2009