Fluorescence imaging of experimental rheumatoid arthritis in vivo using a fast flying-spot scanner

J. Berger; J. Voigt; F. Seifert; B. Ebert; R. Macdonald; I. Gemeinhardt; O. Gemeinhardt; J. Schnorr; M. Taupitz; A. Vater; S. Vollmer; K. Licha; M. Schirner

doi:10.1364/ECBO.2007.6631_32

Novel Optical Instrumentation for Biomedical Applications III
Proceedings of SPIE-OSA Biomedical Optics (Optica Publishing Group, 2007),
paper 6631_32
•https://doi.org/10.1364/ECBO.2007.6631_32

Fluorescence imaging of experimental rheumatoid arthritis in vivo using a fast flying-spot scanner

J. Berger, J. Voigt, F. Seifert, B. Ebert, R. Macdonald, I. Gemeinhardt, O. Gemeinhardt, J. Schnorr, M. Taupitz, A. Vater, S. Vollmer, K. Licha, and M. Schirner

European Conference on Biomedical Optics 2007

Munich Germany
17–21 June 2007
ISBN: 9780819467751

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J. Berger, J. Voigt, F. Seifert, B. Ebert, R. Macdonald, I. Gemeinhardt, O. Gemeinhardt, J. Schnorr, M. Taupitz, A. Vater, S. Vollmer, K. Licha, and M. Schirner, "Fluorescence imaging of experimental rheumatoid arthritis in vivo using a fast flying-spot scanner," in Novel Optical Instrumentation for Biomedical Applications III, C. Depeursinge, ed., Vol. 6631 of Proceedings of SPIE-OSA Biomedical Optics (Optica Publishing Group, 2007), paper 6631_32.

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Abstract

We have developed a flying-spot scanner for fluorescence imaging of rheumatoid arthritis in the near infrared (NIR) spectral range following intravenous administration of contrast agents. The new imaging system has been characterized with respect to linearity, dynamic range and spatial resolution with the help of fluorescent phantoms. In vivo experiments were performed on an animal model of rheumatoid arthritis. Finally, NIR-fluorescence images of early stages of joint inflammation have been compared with findings from contrast enhanced MR imaging and histology.

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