Expand this Topic clickable element to expand a topic
Skip to content
Optica Publishing Group

Barium titanate nanoparticles used as second harmonic radiation imaging probes for cell imaging

Not Accessible

Your library or personal account may give you access


Luminescent markers play a key role in imaging techniques for life science since they provide a contrast mechanism between signal and background. We describe a new type of marker using second harmonic generation (SHG) from noncentrosymmetric BaTiO3 nanocrystals. These nanoparticles are attractive due to their stable, non-saturating and coherent signal with a femtosecond-scale response time and broad flexibility in the choice of excitation wavelength. In this paper, we report the use of nanoparticles for cell imaging. We first stabilized the BaTiO3 nanoparticles in suspension and characterized the optical properties. We also demonstrated the functionalization of BaTiO3 nanoparticles by conjugating IgG antibody on the surface of the nanoparticles. These functionalized nanocrystals are capable of specific labeling the antigens of interest.

© 2009 OSA/SPIE

PDF Article
More Like This
Second-harmonic efficiency of single barium titanate nanoparticles used as biomarkers for cells imaging

R. Grange, C.-L. Hsieh, Y. Pu, and D. Psaltis
CL2_5 The European Conference on Lasers and Electro-Optics (CLEO_Europe) 2009

Harmonic Holographic Microscopy Using Nanoparticles as Probes for Three-Dimensional Cell Imaging

Chia-Lung Hsieh, Rachel Grange, Ye Pu, and Demetri Psaltis
CFA6 Conference on Lasers and Electro-Optics (CLEO) 2009

Imaging Cells with Second-Harmonic Generation Active Nanocrystals

Chia-Lung Hsieh, Rachel Grange, Ye Pu, and Demetri Psaltis
BTuC8 Biomedical Optics (BIOMED) 2010


You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
Login to access Optica Member Subscription

Select as filters

Select Topics Cancel
© Copyright 2022 | Optica Publishing Group. All Rights Reserved