Enhancement of Cancerous/Normal Tissue Contrast via Combined White Light and Fluorescence Image Processing: Initial Investigation ex vivo

Angelos A. Kalitzeos; Azhar Zam; Florian Stelzle; Eckhart G. Hahn; Martin Raithel; Alexandre Douplik

doi:10.1364/ECBO.2009.7371_0N

Novel Optical Instrumentation for Biomedical Applications IV
Proceedings of SPIE-OSA Biomedical Optics (Optica Publishing Group, 2009),
paper 7371_0N
•https://doi.org/10.1364/ECBO.2009.7371_0N

Enhancement of Cancerous/Normal Tissue Contrast via Combined White Light and Fluorescence Image Processing: Initial Investigation ex vivo

Angelos A. Kalitzeos, Azhar Zam, Florian Stelzle, Eckhart G. Hahn, Martin Raithel, and Alexandre Douplik

European Conference on Biomedical Optics 2009

Munich Germany
14–18 June 2009
ISBN: 9780819476470

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TISSUE AND SPECIMEN IMAGING II (TSIII)

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A. A. Kalitzeos, A. Zam, F. Stelzle, E. G. Hahn, M. Raithel, and A. Douplik, "Enhancement of Cancerous/Normal Tissue Contrast via Combined White Light and Fluorescence Image Processing: Initial Investigation ex vivo," in Novel Optical Instrumentation for Biomedical Applications IV, C. Depeursinge and I. Vitkin, eds., Vol. 7371 of Proceedings of SPIE-OSA Biomedical Optics (Optica Publishing Group, 2009), paper 7371_0N.

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Abstract

In the current study we try to optimise the cancerous/normal tissue contrast perception using white light and autofluorescence image processing. We deconvolved the RGB channels of both white light and autofluorescence images pixel by pixel and pointed out the best contrast enhancement technique, manipulating each channel seperately. By using false-color mapping according to a particular Look-Up Table, the borders between normal and cancerous area of the tissue are better delineated. Cancer tissue identification was confirmed by the histological examination that followed our investigation.

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