Blood flow measurement in the in vivo mouse model by the combination of Doppler OCT and the signal power decrease in Spectral Domain OCT

Julia Walther; Gregor Mueller; Henning Morawietz; Edmund Koch

doi:10.1364/ECBO.2009.7372_1Y

Optical Coherence Tomography and Coherence Techniques IV
Proceedings of SPIE-OSA Biomedical Optics (Optica Publishing Group, 2009),
paper 7372_1Y
•https://doi.org/10.1364/ECBO.2009.7372_1Y

Blood flow measurement in the in vivo mouse model by the combination of Doppler OCT and the signal power decrease in Spectral Domain OCT

Julia Walther, Gregor Mueller, Henning Morawietz, and Edmund Koch

European Conference on Biomedical Optics 2009

Munich Germany
14–18 June 2009
ISBN: 9780819476487

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J. Walther, G. Mueller, H. Morawietz, and E. Koch, "Blood flow measurement in the in vivo mouse model by the combination of Doppler OCT and the signal power decrease in Spectral Domain OCT," in Optical Coherence Tomography and Coherence Techniques IV, P. Anderson and B. Bouma, eds., Vol. 7372 of Proceedings of SPIE-OSA Biomedical Optics (Optica Publishing Group, 2009), paper 7372_1Y.

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Abstract

Blood flow measurement with spectrometer-based Fourier domain optical coherence tomography (FD OCT) is limited by the motion-induced signal fading and the resulting reduction of flow sensitivity. In this study, a combination of the established Doppler OCT and the numerically simulated signal damping due to obliquely moved scatterers is used to estimate the systolic blood flow velocities in the in vivo mouse model at which the standard Doppler OCT does not work any longer.

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